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Ritonavir or lopinavir/ritonavir greatly raise plasma concentrations of oxycodone in nutritious human volunteers as a result of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin significantly minimizes plasma concentrations of oxycodone because of sturdy induction of CYP3A4.After some time, The body may perhaps depend upon the medication to operate.